ODCs

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1 OMIM reference -
1 associated gene
No signs/symptoms info

PROTEIN INTERACTIONS: 1

3 OMIM references -
3 associated genes
5 signs/symptoms

Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome

Isolated scaphocephaly


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	ALX1	(0.52)	ALX4

Citations in the biomedical literature:

Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome		Isolated scaphocephaly
	Synonym(s): - ALX1-related frontonasal dysplasia		Synonym(s): - Isolated dolichocephaly - Non-syndromic sagittal synostosis

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare maxillo-facial surgical disease - Rare otorhinolaryngologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 3 OMIM references - No MeSH references

Isolated scaphocephaly
	Very frequent - Dolichocephaly / scaphocephaly Occasional - Autosomal dominant inheritance - Cranial hypertension - Frontal bossing / prominent forehead - Prominent occiput / occipital bossing
Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome
(no data available)